Table 1.
Baseline Patient Characteristics
| Parameters | Alpha Lipoic Acid | |||
|---|---|---|---|---|
| N of pts (322) | ||||
| Dose (mg) | 400 | 600 | 800 | 1200 |
| N | 83 | 78 | 80 | 81 |
| Age (years) | 51.6 ± 9.2 | 50.3 ± 8.7 | 54.8 ± 10.6 | 55.2 ± 10.9 |
| M/F | 40/43 | 38/40 | 39/41 | 41/40 |
| Smoking status (M/F) | 11/13 | 14/13 | 12/11 | 9/11 |
| Weight (kg) | 75.2 ± 6.6 | 74.9 ± 6.4 | 75.1 ± 6.7 | 75.4 ± 7.0 |
| Height (m) | 1.67 ± 0.09 | 1.67 ± 0.09 | 1.66 ± 0.08 | 1.65 ± 0.07 |
| BMI (kg/m2) | 27.1 ± 2.1 | 26.8 ± 1.9 | 27.2 ± 2.2 | 27.7 ± 2.5 |
| SBP (mmHg) | 136.2 ± 6.1 | 135.8 ± 5.9 | 136.9 ± 6.7 | 135.7 ± 5.7 |
| DBP (mmHg) | 82.1 ± 4.6 | 81.8 ± 4.2 | 82.3 ± 4.7 | 82.5 ± 4.9 |
| FPG (mg/dl) | 95.1 ± 12.1 | 95.4 ± 12.4 | 94.6 ± 11.8 | 94.8 ± 11.9 |
| TC (mg/dl) | 216.1 ± 14.8 | 215.6 ± 14.5 | 214.4 ± 13.7 | 215.9 ± 14.8 |
| LDL-C (mg/dl) | 147.3 ± 8.5 | 146.3 ± 8.2 | 144.6 ± 7.5 | 146.8 ± 8.6 |
| HDL-C (mg/dl) | 42.5 ± 5.8 | 42.7 ± 5.9 | 43.1 ± 6.1 | 42.4 ± 5.7 |
| Tg (mg/dl) | 131.6 ± 15.8 | 133.1 ± 16.3 | 133.6 ± 16.8 | 133.5 ± 16.7 |
| Hs-CRP (mg/l) | 1.3 ± 0.5 | 1.4 ± 0.6 | 1.3 ± 0.5 | 1.5 ± 0.7 |
Note: Data are expressed as mean ± standard deviations.
Abbreviations: M, males; F, females; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; TC, total cholesterol; LDL-C, low-density lipoprotein-cholesterol; HDL-C, high-density lipoprotein-cholesterol; Tg, triglycerides; Hs-CRP, high-sensitivity C-reactive protein.