Fig 7. Cellular pathways associated with genes expressed by microglia and developmental alterations in the preterm cortex.

Left: Genes expressed by microglia in the fetal cortex and significantly associated with group differences in T1w/T2w contrasts across at least 3 age windows are shown. Dark blue indicates periods where gene expression and T1w/T2w contrast were significantly correlated for each gene (FDR p < 0.05) across the preterm period. Right: PPI networks derived using STRING. Top functional enrichments of molecular pathways are shown where applicable. Genes associated with listed enriched pathway and genes differentially expressed in an animal model of preterm brain injury are highlighted. See https://github.com/garedaba/baby-brains/tree/master/data/gene_lists. FDR, false discovery rate; PPI, protein–protein interaction; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins.