Table 3. Multivariate Cox regression analysis of mortality factors in the entire cohort and in females that only received chemotherapy.
| Characteristics | OS in the entire cohort | OS in patients only receiving chemotherapy | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| NLRa | ||||||
| < 2.5 | Ref | - | - | Ref | - | - |
| ≥ 2.5 | 2.12 | 1.32–3.39 | 0.002 | 2.68 | 1.46–4.92 | 0.001 |
| Age | 1.00 | 0.98–1.01 | 0.748 | 1.00 | 0.98–1.03 | 0.821 |
| hCCIb | ||||||
| Score 6 | Ref | - | - | Ref | - | - |
| Score ≥ 7 | 0.77 | 0.45–1.32 | 0.342 | 0.65 | 0.30–1.41 | 0.281 |
| Tumor size | ||||||
| T0-3 | 1 | - | - | Ref | - | - |
| T4 | 1.15 | 0.71–1.85 | 0.577 | 0.72 | 0.37–1.39 | 0.325 |
| Lymph node status | ||||||
| N0-1 | Ref | - | - | Ref | - | - |
| N2-3 | 1.07 | 0.70–1.64 | 0.758 | 1.35 | 0.75–2.43 | 0.319 |
| Site of metastases | ||||||
| 1 organ | Ref | - | - | Ref | - | - |
| ≥ 2 organs | 1.17 | 0.77–1.77 | 0.473 | 0.97 | 0.56–1.68 | 0.912 |
| Chemotherapy | ||||||
| No | Ref | - | - | - | - | - |
| Yes | 0.41 | 0.26–0.64 | <0.001 | - | - | - |
aNeutrophil-to-lymphocyte ratio
bhCCI, hypertension-augmented Charlson comorbidity index