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. 2020 Nov 23;14(11):e0008834. doi: 10.1371/journal.pntd.0008834

Fig 6. Protection of the IS Balb/c mice immunized with the cell culture based and the mouse brain derived vaccines.

Fig 6

Groups of 10 IS Balb/c mice were immunized three times at two weeks intervals with 20μg of the two vaccine preparations. The control group of the IS Balb/c mice (n = 7) was mock immunized with PBS. All animals were challenged with 100 PPFU CCHFV Turkey-Kelkit06 strain two weeks after the last immunization. The mice were monitored twice daily for the cumulative mean symptom scores (A), the daily variations in weight as percentages compared to before the virus challenge (B), body temperature (C), and geometric mean time to death and survival (D). The animals were monitored for three weeks after the challenge. The standard deviations are shown as error bars. Log rank (Mantel-Kox) test was utilized for survival statistics, **** p<0.0001. A one-way ordinary ANOVA was used to analyse weight loss over time between two vaccinated groups, ***p<0.0005.