Table 4.
Delivery of Drug/Natural Macromolecular Bioactive Substances Systems with Effective Control of Chronic/Diabetic Wounds
| Drugs/ | Drug Delivery Systems | Functions | References |
|---|---|---|---|
| Deferoxamine(DFO) | TDDS; multifunctional hydrogels; nanofibrous/scaffolds. |
Increases HIF-1α expression; upregulate VEGF expression. |
[132–134] |
| Statins | Tissue engineering scaffold | In situ eNOS/NO up-regulation. | [121] |
| Insulin | Injectable hydrogels | pH and glucose dual-responsive hydrogels. | [137] |
| Curcumin | Gelatin microspheres; chitosan nanoparticles. |
MMP9-responsive drug-release system; anti-inflammatory and antioxidant. |
[139–141] |
| Dimethyloxalylglycine (DMOG) | Porous electrospun fibrous membrane | Controllable released DMOG drugs | [138] |
| Ciprofloxacin | CS and cyclodextrin polymer sponges | local drugs release without risk of toxicity to the body. | [122] |
| Snail glycosaminoglycan | Sulfated polysaccharide | Accelerated the healing of full-thickness wounds in diabetic mice skin. | [123] |
| Kirenol | Diterpenoid | Encourage angiogenesis, fibroblast propagation | [124] |
| Quercetin | Collagen-nanomaterial-drug hybrid scaffold | Promoting collagen deposition and angiogenesis in diabetic wound repair. | [125] |
| Herbal extract of didymocarpus pedicellatus | pDMAEMA−HA hydrogel | Enhanced cutaneous wound repair as well as high level of cellular repair. | [126] |