Figure 6.

Relationship between cytokine response module expression at admission in COVID-19 and clinical outcome

(A) Geometric mean expression of IL-1β and IL-6 response modules in transcriptomic profiles of blood leukocytes collected from 101 COVID-19 and 24 non-COVID-19 patients. In this study, samples were collected from patients at a median of 3.37 days from admission to hospital (Overmyer et al., 2020). p values derived from two-tailed Mann-Whitney test.

(B) In patients from this cohort who were not admitted to ITU, the relationship between expression of cytokine response modules, or a previously validated T cell module (Pollara et al., 2017), and the number of hospital-free days at day 45 (HFD-45) following hospital admission (whereby zero days indicated continued admission or death) is shown. Statistical assessment of correlation made by Spearman Rank correlation. r = correlation coefficient.