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. 2020 Dec 7;24(1):101903. doi: 10.1016/j.isci.2020.101903

Figure 2.

Figure 2

Comparison of SARS-CoV-2 Nsp113-127 to SARS-CoV Nsp1

(A) Alignment of residues 13–127 of Nsp1 with conserved residues highlighted in black.

(B) Ribbon representation of SARS-CoV-2 (PDB: 7K3N) and SARS-CoV (PDB: 2HSX) Nsp113-127. β4 (shown in cartoon representation) is extended in the SARS-CoV-2 structure allowing for H-bonding with and formation of β5, which is absent in the SARS-CoV Nsp1 structure. The loop region (and equivalent in SARS-CoV Nsp1) stabilized through interaction between β4 and β5 is colored in purple.

(C) Comparison of electrostatic surface potential of SARS-CoV-2 and SARS-CoV Nsp113-127.