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. 2020 Dec 7;24(1):101903. doi: 10.1016/j.isci.2020.101903

Figure 3.

Figure 3

Comparison of the structure of SARS-CoV-2 Nsp113-127 to structural homologs

(A) Cartoon representation of the SARS-CoV-2 Nsp113-127 structure with non-conserved residues between SARS-CoV-2 and SARS-CoV highlighted in magenta.

(B) SARS-CoV-2 Nsp113-127 (PDB: 7K3N) is shown in green; SARS-CoV Nsp1 (PDB: 2HSX), TGEV Nsp1 (PDB: 6IVC), and PEDV Nsp1 (PDB: 5XBC) are shown in gray with noticeable structural differences (compared to SARS-CoV-2) highlighted in red. Distinctive secondary structure features from the SARS-CoV-2 Nsp113-127 structure are labeled.

(C) Homology model of β-barrel domain of Nsp1 from MERS-CoV. Conserved residues between MERS-CoV and SARS-CoV-2 Nsp1 are highlighted in magenta and the N- and C-termini are labeled.