. 2020 Nov 10;12(12):e12921. doi: 10.15252/emmm.202012921

Table 3.

ROC analyses to discriminate cognitively unimpaired Aβ‐positive from Aβ‐negative individuals.

	AUC (95% CI) CU Aβ+ vs. Aβ−
	CSF Aβ42/40 (A−: 250; A+: 131)	Aβ PET visual read (A−: 287; A+: 42)	Aβ PET CL12 (A−: 278; A+: 53)
CSF Mid‐p‐tau181	0.683 (0.627–0.739)	0.814 (0.748–0.881)	0.748 (0.673–0.824)
CSF N‐p‐tau181	0.763 (0.710–0.816) ^a	0.858 (0.787–0.928) ^c	0.855 (0.794–0.916) ^a
CSF N‐p‐tau217	0.794 (0.744–0.844) ^a	0.833 (0.825–0.941) ^g	0.875 (0.819–0.931) ^a
CSF Mid‐p‐tau231	0.809 (0.761–0.856) ^a , ^b	0.894 (0.833–0.954) ^a	0.894 (0.845–0.943) ^a , ^j
CSF t‐tau	0.669 (0.612–0.726) ^c , ^d , ^e , ^f	0.793 (0.725–0.862) ^b , ^e , ^f , ^g	0.722 (0.646–0.799) ^a , ^d , ^e , ^f
Plasma N‐p‐tau181	0.670 (0.612–0.728) ^b , ^e , ^f	0.671 (0.581–0.762) ^d , ^e , ^f , ^g , ^h	0.729 (0.656–0.801) ^b , ^e , ^f
Plasma NfL	0.626 (0.567–0.685) ^d , ^e , ^f	0.660 (0.574–0.745) ^d , ^e , ^f , ^g , ⁱ	0.628 (0.545–0.710) ^d , ^e , ^f , ^g , ⁱ , ^k

Aβ42, amyloid‐β 42; Aβ40, amyloid‐β 40; AUC, area under the curve; CI, confidence interval; CL, Centiloid; CSF, cerebrospinal fluid; Mid, mid‐region; N, N‐terminal; NfL, neurofilament; p‐tau, phosphorylated tau; t‐tau, total tau; PET, positron emission tomography.

ROC analyses to test whether each p‐tau biomarker discriminates between Aβ‐positive (A+) and Aβ‐negative individuals (A−), as defined by the CSF Aβ42/40 ratio, Aβ PET visual read or Aβ PET using a cut‐off of CL12. We also included CSF t‐tau and plasma NfL for comparison. Aβ PET was performed in 331 participants, and Centiloid scale was available in all of them; two participants did not have visual read assessment. The exact P‐values are shown in Appendix Table S1. AUCs differences were tested using the DeLong test. The significant differences were as follows:

^{^a}

P < 0.001 compared to CSF Mid‐p‐tau181.

^{^b}

P < 0.01 compared to CSF N‐p‐tau181.

^{^c}

P < 0.05 compared to CSF Mid‐p‐tau181.

^{^d}

P < 0.001 compared to CSF N‐p‐tau181.

^{^e}

P < 0.001 compared to CSF N‐p‐tau217.

^{^f}

P < 0.001 compared to CSF Mid‐p‐tau231.

^{^g}

P < 0.01 compared to CSF Mid‐p‐tau181.

^{^h}

P < 0.01 compared to CSF t‐tau.

^ⁱ

P < 0.05 compared to CSF t‐tau.

^{^j}

P < 0.05 compared to CSF N‐p‐tau181.

^{^k}

P < 0.05 compared to plasma N‐p‐tau181.