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. Author manuscript; available in PMC: 2021 Oct 27.
Published in final edited form as: Biochemistry. 2020 Oct 13;59(42):4118–4130. doi: 10.1021/acs.biochem.0c00622

Scheme 1.

Scheme 1.

Possible Biosynthetic Pathways of 5S,12S-diHETE and 5S,15S-diHETEa

aIt should be noted that LOXs initially produce hydroperoxides that are subsequently reduced by glutathione peroxidases. The reduced products have been presented for the sake of simplicity.