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. 2020 Nov 16;9:e55800. doi: 10.7554/eLife.55800

Figure 2. Fewer MOG-specific CD4 T cells are present in the CNS of CLP mice.

Figure 2.

(A) Experimental design: C57Bl/6 mice underwent either sham or CLP surgery. EAE induction occurred 5 days after surgery. Mice were perfused 15 days post-EAE induction and CNS was harvested. (B) Representative flow plots for CNS CD4 T cells, gated on lymphocytes, from sham and CLP mice. (C) Frequency and (D) number of CNS CD4 T cells in sham and CLP mice. (E) Representative flow plots for CNS MOG-specific CD4 T cells, gated on total CD4 T cells, from Naive (staining control), sham, and CLP mice. (F) Frequency and (G) number of CNS MOG-specific CD4 T cells in sham and CLP mice. Dashed line indicates staining and number from naive control mouse. Data are representative from two independent experiments with 8–10 mice per group. *p<0.05. Error bars represent the standard error of the mean.

Figure 2—source data 1. Source data for Figure 2.