Table 3. Significant (p < 0.05) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched for genes within 5-kb flanking region of associated SNP for PRA disease.

KEGG	Pathway name	No. of genes	Genes	p-value
Cfa04510	Focal adhesion	14	ACTB, DIAPH1, COL6A3, MYLK4, PPP1R12A, ITGA11, RELN, PDGFD, COL5A2, COL11A1, PIK3R1, FN1, AKT2, KDR	2.56E-03
Cfa04360	Axon guidance	10	ABLIM1, DCC, EPHA4, CXCR4, ROBO1, NTN4, SEMA3C, ROBO2, EPHB1, RASA1	4.57E-03
Cfa04022	cGMP-PKG signaling pathway	10	MYLK4, PDE5A, PPP1R12A, ADRA1B, ATP1A4, ATP1A1, PRKCE, AKT2, ITPR2, VDAC1	1.98E-02
Cfa04971	Gastric acid secretion	6	SSTR2, SLC26A7, MYLK4, ATP1A4, ATP1A1, ITPR2	3.76E-02
Cfa04611	Platelet activation	8	ACTB, MYLK4, PPP1R12A, COL5A2, COL11A1, PIK3R1, AKT2, ITPR2	4.53E-02

SNP, single nucleotide polymorphism; PRA, progressive retinal atrophy; cGMP, cyclic guanosine monophosphate; PKG, protein kinase G.