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. 2020 Nov 15;28(22):115784. doi: 10.1016/j.bmc.2020.115784

Table 3.

Microsomal clearance data for representative compounds of Table 1.

No HLM Clinta MLM Clinta
1 3.0 7.0
6 22 35
7 41 56
8 17 42
10 121 238
12 92 239
27 107 810
36 48 584
42 50 65
48 48 40

aClearance (µL/min/kg protein). HLM (Human liver microsomes), MLM (Mouse liver microsomes).