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. 2020 Dec 1;11(48):4504–4520. doi: 10.18632/oncotarget.27830

Figure 10. Preventive and therapeutic treatment of ASOs in experimental HCC.

Figure 10

HCC was induced by weekly intraperitoneal DEN injection for 25 weeks. Control mice received weekly intraperitoneal 0.9% NaCl injection. DEN-treated mice were intraperitoneally injected with 20 mg/kg HIF-1α ASO, HIF-2α ASO or scrambled ASO twice per week. In the preventive setting, ASO injections started 10 weeks following the first DEN injection (at 15 weeks of age) and persisted for a period of 15 weeks. In the therapeutic setting, ASO injections started 20 weeks following the first DEN injection (at 25 weeks of age) and persisted for a period of 8 weeks. Control mice received scrambled ASO for the same duration of the experiment. Following respective treatment periods, mice were sacrificed and the liver was isolated for further analyses.