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. 2020 Dec 8;41(5):940–951. doi: 10.1038/s41372-020-00874-x

Fig. 1. SARS-CoV-2 viral entry and replication in host.

Fig. 1

The spike (S) glycoproteins of the SARS-CoV-2 virus bind to the ACE2 receptor on the host cell. (2) The TMPRSS2 protein cleaves the S proteins off the viral envelope, (3) allowing for viral entry either by endocytosis or fusion. (4) Single-stranded viral RNA is replicated by host machinery into a large polyprotein. (5) The polyprotein is then cleaved by a viral protease. (6) Viral protein and RNA is then packaged into a nucleocapsid. (7) New virions are assembled and (8) released to further infect the host [12–15].