Figure 6.
Prophylactic Potential of Adoptive Transfer of T Cells, Transduced with the Single Salmonella-Specific TCRα
Intact B10.D2(R101) were i.v. injected with either non-transduced T cells (NTCs) or mixture of individual types of T cells, transduced with the single TCRα as specified. On Day 3. post-adoptive, transfer mice were enterogastrally infected with LD27 (4.0–6.0 x 106 CFU/mouse) of S. typhimurium strain IE 147. Mice without the adoptive transfer were used as the control. The log number of bacterial colony-forming units (lgCFUs) was counted in the spleen of mice on Day 7 post-infection. (A) The lgCFU number per spleen.
(B) The mean lgCFU number per spleen. Data are presented as mean ± SD. One-way ANOVA, corrected with Tukey's multiple comparisons.
NS, not significant. See also Figures S1, S3, and S4.