Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 7;10:21378. doi: 10.1038/s41598-020-78294-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

MIA induces sustained changes in behavior that can show weak correlations with microglial tip process directionality. (a, b) Averaged effects of MIA induced at E12 or E15 on (a) the proportion of time spent in the center of the open field or (b) on the total distance traveled in the open-field test (n = 16 mice in each group). (c, d) Averaged effects of MIA induced at E12 or E15 on (c) the time spent sniffing, or (d) following, a novel mouse in the social interaction test (n = 16 mice in each group). Columns represent the mean ± standard deviation, while dots show data from each mouse. *P < 0.05, **P < 0.01, ***P < 0.001 and N.S.: not significant, unpaired t-test. (e) Experimental scheme showing two-photon imaging and behavioral assay before and after LPS injection. (f, g) Plot of the relationship between behavioral phenotypes and microglial directionality in individual P42 offspring from E12 (f) and E15 (g) MIA mice, before (black dots) and after (red dots) LPS injection. The regression line plots the linear correlation between the two variables; the time spent following was significantly correlated with directionality (P = 0.031, r = 0.75, n = 8 mice, Pearson’s correlation test). For all plots, n = 4 mice before LPS and 4 mice after LPS.