Table 9.

Comparison of morphological properties between E18 and P10 microglia from control (E12 and E15 saline -injected) and MIA (E12 and E15 Poly(I:C) -injected) mice.

Soma area (μm2) (E18 vs. P10)
Mouse, P value	E18	P10	P value	E18	P10	P value
	E12 Ctrl			E12 MIA
Mean ± SD	63.4 ± 15.5	47.6 ± 9.58	< 0.0001	65.7 ± 21.1	49.3 ± 8.24	0.0004
Number of cells	37 (from 4 mice)	26 (from 4 mice)		37 (from 4 mice)	26 (from 4 mice)
	E15 Ctrl			E15 MIA
Mean ± SD	56.6 ± 13.0	45.1 ± 6.45	0.0003	54.8 ± 12.8	46.8 ± 8.16	0.0132
Number of cells	23 (from 4 mice)	25 (from 4 mice)		23 (from 4 mice)	25 (from 4 mice)

Total process length (μm) (E18 vs. P10)
Mouse, P value	E18	P10	P value	E18	P10	P value
	E12 Ctrl			E12 MIA
Mean ± SD	129 ± 48.9	314 ± 102	< 0.0001	132 ± 59.2	276 ± 60.4	< 0.0001
Number of cells	24 (from 4 mice)	14 (from 4 mice)		24 (from 4 mice)	14 (from 4 mice)
	E15 Ctrl			E15 MIA
Mean ± SD	113 ± 37.2	266 ± 14.9	< 0.0001	122 ± 24.4	266 ± 40.9	< 0.0001
Number of cells	12 (from 4 mice)	12 (from 4 mice)		12 (from 4 mice)	12 (from 4 mice)

Number of processes (E18 vs. P10)
Mouse, P value	E18	P10	P value	E18	P10	P value
	E12 Ctrl			E12 MIA
Mean ± SD	3.13 ± 0.80	4.93 ± 1.00	< 0.0001	3.25 ± 0.90	4.50 ± 0.94	0.0002
Number of cells	24 (from 4 mice)	14 (from 4 mice)		24 (from 4 mice)	14 (from 4 mice)
	E15 Ctrl			E15 MIA
Mean ± SD	2.92 ± 0.90	4.67 ± 0.65	< 0.0001	3.08 ± 0.51	4.58 ± 0.67	< 0.0001
Number of cells	12 (from 4 mice)	12 (from 4 mice)		12 (from 4 mice)	12 (from 4 mice)
	E12 Ctrl			E12 MIA
Mean ± SD	5.63 ± 2.98	33.4 ± 15.8	< 0.0001	5.96 ± 3.59	29.3 ± 6.07	< 0.0001
Number of cells	24 (from 4 mice)	14 (from 4 mice)		24 (from 4 mice)	14 (from 4 mice)
	E15 Ctrl			E15 MIA
Mean ± SD	7.25 ± 3.19	35.6 ± 5.05	< 0.0001	7.00 ± 2.34	37.0 ± 6.08	< 0.0001
Number of cells	12 (from 4 mice)	12 (from 4 mice)		12 (from 4 mice)	12 (from 4 mice)