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. 2020 Dec 7;10:21364. doi: 10.1038/s41598-020-78206-4

Figure 7.

Figure 7

A schematic of the proposed mechanism of TGF-β-mediated regulation of fibrous tissue differentiation from sclerotome. We hypothesize that TGFβ regulates fibrous tissue differentiation by first regulating non-canonical signaling through ERK1/2 (1), which is required for Scx mRNA expression (2). We propose that subsequently, Scx and Smad3 cooperate to regulate the ECM markers, Fmod and Adamtsl2 (3).