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. 2020 Dec 7;10:21360. doi: 10.1038/s41598-020-77800-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PP VII enhances macrophage priming to an immune activated pattern dependent on STING. (a–c) siSTING (a) and siIRF3 (b) transfected RAW 264.7s were pretreated with or without PP VII and primed with IFN-γ for RT-qPCR analysis. CD86 expression was qualified by FACs analysis from Indicated cells that were stimulated as in a (c). Data are depicted as mean + SD of triplicate samples from two independent experiments. ***p < 0.001, **p < 0.01, *p < 0.05, ns no significant.