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. 2020 Dec 7;10:21360. doi: 10.1038/s41598-020-77800-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PP VII boosts macrophage activity relying on STING. (a–c) RAW 264.7s and THP-1s were pretreated with C-176 and H-151 respectively then primed with IFN-γ in absence or presence of PP VII (a,b). RAW 264.7s with DMXAA pretreatment were primed with IFN-γ following inhibitor incubation (c). RT-qPCR analysis of triplicates from two independent experiments is shown as mean + SD. ***p < 0.001, **p < 0.01, *p < 0.05, ns no significant.