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. 2020 Dec 7;10:21360. doi: 10.1038/s41598-020-77800-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PP VII exerted anti-tumor efficacy dependent on STING activating while induces chemokines intratumorally. (a–e) C57BL/6 mice (n = 5 per group) with LLC tumors were injected i.p. with vehicle, DMXAA (15 mg/kg), PP VII (7.5 mg/kg), or the combination of PP VII and C-176 (750 nM per mouse) five times (indicated by bule arrows in (b). Gross appearance of the tumors extracted from tumor-bearing mice at day 15 after treatment initiation (a). Tumor volumes were measured at indicated time points (b) and the individual tumor volumes for each treatment are also presented (d). Mice were weighted as indicated (c). Tissue sections from LLCs tumors received indicated treatments were analyzed by qPCR (e). Data are depicted as mean + SD of six samples from pools of two mice. ***p < 0.001, **p < 0.01, *p < 0.05, ns no significant.