Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 7;10:21342. doi: 10.1038/s41598-020-78508-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Xenograft mouse model shows larger and a greater number of tumor nodules as well as more frequent hepatosplenic infiltration in cell lines with higher expression of NANOG and HOXA9. (A) U2940 cells formed larger and more tumor nodules. (B) Histologically, the U2940 xenograft is composed of large lymphoid cells with a brisk mitotic activity (HE stain, 1000X) and CD20 positivity (1000X). (C), (D) The DLBCL cells inoculated via the tail vein show dense infiltration in the liver (upper in C, HE stain, 200X) and spleen (lower in D, HE stain, 200X). (E) The mean xenograft tumor numbers in each mouse are depicted for six cell lines (LCL, 4; HBL-2, 1; HT, 1; SU, 1.7; U2932, 1.8; U2940, 3.3). (F) The mean tumor size (mm) in each cell line group (LCL, 6.5; HBL-2, 5.9; HT, 5.1; SU, 3.6; U2932, 5.4; U2940, 5.6). (G) The mean frequency of hepatosplenic infiltration in each cell line group (LCL, 100%; HBL-2, 38%; HT, 25%; SU, 50%; U2932, 67%; U2940, 88%). The detailed data are listed in Supplementary Table S3. *p < 0.05, **p < 0.01, Student t-test.