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. 2020 Dec 7;10:21391. doi: 10.1038/s41598-020-78369-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PZ-DHA and metabolites were detected in various organs of PZ-DHA-treated Balb/c female mice. PZ-DHA (100 mg/kg) was administered by intraperitoneal injection to Balb/c female mice and liver, lungs, kidneys, spleen and brain were harvested. Organs were homogenized and PZ-DHA in (A) liver, kidneys, lungs, spleen, and brain was identified and quantified using a calibration curve. The abundance of (B) 4,4′,6′-tri-O-methyl-phloridzin docosahexaenoate in liver, kidneys, lungs, and serum) and (C) phloridzin docosahexaenoate-4,4′-di-O-sulphide in the liver was determined in PZ-DHA equivalence.