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. 2020 Dec 7;10:21391. doi: 10.1038/s41598-020-78369-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed scheme for the fate of PZ-DHA upon intraperitoneal administration into Balb/c female mice. Absorption of intraperitoneally administered PZ-DHA via ① superior mesenteric vein and ② inferior mesenteric vein; ③ Phase II metabolism of PZ-DHA in the liver; ④ Biliary secretion and entero-hepatic circulation of PZ-DHA and its metabolites; Distribution of PZ-DHA and its metabolites via ⑤ inferior vena cava, ⑥ left and right carotid arteries, ⑦ bronchial arteries branched from the descending aorta; ⑧ hepatic artery branched from descending aorta, ⑨ splenic artery, and ⑩ renal arteries branched from descending aorta; ⑪ PZ-DHA may be excreted via kidneys. Solid-lined arrows (→) indicate confirmed processes and dashed-line arrows (⇢) indicate suggested potential processes, which need to be confirmed in future studies. BBB blood brain barrier; METs methyltransferases; UGTs UDP-glucuronosyltransferase; SULTs sulphotransferases.