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. 2020 Dec 4;153(3):e202012729. doi: 10.1085/jgp.202012729

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© 2020 Harris

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Figure 5. — Effects of cut and paste of cMyBP-C N-terminal domains on force in skinned myocytes. (A and B) Normalized tension–pCa relationships in WT myocytes (A) or HO Spy-C myocytes (B); before TEVp treatment (control, blue), after TEVp treatment (red), and after incubation with rC0C7-sc (green). (C and D) Summary data showing average pCa₅₀ values for each condition in WT (C) and HO Spy-C myocytes (D). Loss of C0–C7 domains after TEVp treatment caused a decrease in Ca²⁺ sensitivity to tension that was reversed by ligation of rC0-C7-sc in HO but not WT myocytes. (E and F) k_tr data from WT (E) and HO (F) myocytes showing an increase in relative k_tr at intermediate [Ca²⁺] after TEVp treatment that was reversed by ligation of rC0-C7-sc in HO but not WT myocytes. Data reprinted from Napierski et al. (2020).