Frequency of IDH1 R132 and IDH2 R172 mutations in various malignancies (A). All IDH1 R132 mutated tumors (B), glioma (C), cholangiocarcinoma (D) and chondrosarcoma (E). IDH2 R172 mutations in all tumor types (F), glioma (G), AITL/PTCL (H), cholangiocarcinoma (I), sinonasal carcinoma (including 16 SNUC/LCNEC and 2 poorly differentiated carcinomas with glandular differentiation [ref. 10], J), and chondrosarcoma (K). Abbreviations: IHCC, intrahepatic cholangiocarcinoma; PTCL, peripheral T-cell lymphoma; AITL, angioimmunoblastic T-cell lymphoma; SNUC/LCNEC, sinonasal undifferentiated/large cell neuroendocrine carcinoma; nos, not otherwise specified; ca, carcinoma.