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14H7 mAb shows a range in staining intensity in IDH2 R172K mutated gliomas. Anaplastic oligodendroglioma (H&E, A) stains strongly for 14H7 (B) and in another case (H&E, C), anti-IDH2 R172K is rather weak (D) but a distinct granular pattern indicative of mitochondrial localization of the mutant IDH2 protein is apparent at high magnification (inset, D).
