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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: J Leukoc Biol. 2020 Jul 29;108(4):1361–1368. doi: 10.1002/JLB.4MR0620-091R

Table 1.

Summary of selected studies in NK cell dysfunction in the cancer

NK cell function Context Species References
Decreased degranulation, decreased IFN-γ Intratumoral NK cells from Non-small cell lung cancer Human [56, 57]
Decreased cytotoxicity NK cells from peritoneal effusions in ovarian cancer patients Human [58]
Decreased cytotoxicity, increased expression of NKG2A, decreased IFN-γ NK cells from hepatocellular carcinoma compared to liver derived NK cells from healthy donors Human [59]
Decreased cytotoxicity Peripheral blood NK cells from pancreatic, gastric, and colorectal cancer patients compared to healthy donors Human [60]
Decreased degranulation, decreased IFN-γ NK cells adoptively transferred into mice with leukemia Murine [61]
Decreased cytotoxicity, decreased activating receptors Cancer associated fibroblasts co-cultured with NK cells Human [77–79]
Decreased cytotoxicity, decreased cytokine secretion Myeloid derived suppressor cells from hepatocellular carcinoma co-cultured with NK cells Human [80]