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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Curr Opin Neurol. 2020 Aug;33(4):451–461. doi: 10.1097/WCO.0000000000000834

2. Examples of the most common quantitative imaging approaches in the most prevalent degenerative ataxias among autosomal recessive, autosomal dominant and sporadic ataxias, namely Friedreich ataxia (FRDA), spinocerebellar ataxia type 3 (SCA3), and cerebellar multiple system atrophy (MSA-C).

2.

Profiles of cerebellar atrophy from voxel-wise (a, c) and region-of-interest (b) analyses are displayed in hot colors (top). Fractional anisotropy findings from diffusion-weighted imaging, reflecting white matter microstructural integrity, are shown in cool colors (middle) from voxel-wise (d), region-of-interest (e), and tract-based spatial statistics (TBSS) (f) analyses. These images reflect different analysis approaches, but exemplify their common utility in defining key disease characteristics. The bottom panels (g-i) display neurochemical abnormalities in MR spectra obtained at 7T from a vermis voxel (shown in yellow on the right) in individuals with ataxia relative to a control spectrum. The alterations visible in the spectra are marked with arrows. tNAA: total N-acetylaspartate; tCr: total Creatine; mI: myo-Inositol. The panels in this figure are based on data from prior publications [11, 25, 33, 45] or unpublished data.