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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Alcohol Clin Exp Res. 2020 Jul 26;44(9):1769–1782. doi: 10.1111/acer.14407

Figure 4.

Figure 4.

OFC inactivation suppressed reinstatement of 10% ethanol seeking in both male and female rats. (A) Saline treated rats (white bars) exhibited significant reinstatement relative to the final day of extinction (black bars). CNO treatment (gray bars) suppressed total nosepokes relative to saline treatment, and decreased responding to extinction levels. This was true for male and female rats. OFC inactivation also decreased total number of trials initiated (B), increased latency to initiate trials (C), and marginally (but significantly) decreased number of well entries following conditioned cues (D). Total well entries (D) and latency to enter the well (F) were not impacted.