OFC inactivation suppressed reinstatement of sucrose seeking in both male and female rats. As with 10% ethanol, total number of nosepokes (A), number of initiated trials (B), and well entries after cue (E) were decreased after OFC inactivation, and total well entries (D) and latency to enter the well (F) were not affected. Latency to initiate trials was increased (C), but not significantly. Although differences were observed between male and female rats, particularly after OFC inactivation (e.g., A, B, and E), there were no significant effects of sex and no significant interaction effects between sex and treatment.