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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Brain Stimul. 2020 Oct 15;13(6):1774–1783. doi: 10.1016/j.brs.2020.10.006

Fig. 5.

Fig. 5.

Diagram demonstrating the experimental design of neuromodulation via EPG. Virus encoding to the EPG was stereotaxicly injected into the left S1, contralateral to the denervated forepaw (Den-EPG). Denervated control rats were injected with a virus encoding for a fluorescence protein (Den-Control). An electromagnet was placed over the left S1 starting three weeks following stereotaxic injection. The electromagnet delivered magnetic field stimulation for 16 minutes once a day, for 30 days. Immunostaining images in the primary somatosensory cortex showing EPG expression in fixed brain sections using anti-FLAG antibody in left S1, and right, non-injected S1. On the left S1, EPG can be detected with high-magnification of 100× (upper panel, scale bar= 10 μm), 40× (Scale bar=20 μm) and 4× magnification (Scale bar = 50 μm). No EPG was detected in secondary somatosensory cortex (S2), and in the right, non-injected S1. 4× magnification (Scale bar = 50 μm). No EPG was detected in secondary somatosensory cortex (S2), and in the right, non-injected S1.