Figure 1:

B6N mice have higher levels of innate immune transcripts compared with B6J mice. (A) Experiment schematic, To assess transcript abundance between substrains, B6N and B6J mice were euthanized, the mPFC freshly dissected, RNA extracted and qRT-PCR analysis was performed. (B) Levels for each transcript are shown as log2 fold-change values, normalized to Gusb (n=6/group). Data represented as mean + SEM (analyzed by Welch’s t-test, **** P <0.0001, *** P < 0.0002, ** P < 0.0021, * P < 0.05).