Figure 3:

Poly(I:C) does not change drinking in B6N mice. (A) Experiment schematic: poly(I:C) or saline was injected every 4th day while male B6J and B6N mice underwent EOD drinking. The procedure lasted for 32 days (i.e. 8 injections). (B,E) Ethanol intake (g/kg/24 h) for B6J and B6N mice, respectively; (C,F) preference for EtOH for B6J and B6N mice, respectively; (D,G) Total fluid intake (g/kg/24 h) for B6J and B6N mice, respectively. (H) Escalation of ethanol intake (g/kg/24 h) for B6J and B6N mice, respectively; (I) Escalation of preference for EtOH for B6J and B6N mice, respectively; (J) Escalation of total fluid intake (g/kg/24 h) for B6J and B6N mice, respectively. Drinking data represented as mean + SEM analyzed by two-way ANOVA with Bonferroni post-hoc tests. Escalation data represented as mean + SEM analyzed by one-way ANOVA with Tukey post-hoc tests (**** P < 0.0001, *** P < 0.0002, ** P < 0.0021, * P < 0.05).