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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Alcohol Clin Exp Res. 2020 Aug 2;44(9):1760–1768. doi: 10.1111/acer.14410

Figure 4:

Figure 4:

Chronic poly(I:C) and ethanol increases inflammatory response in B6J but not B6N mice. (A) B6N mice treated with poly(I:C) have no significant changes in transcript abundance for innate immune components compared with B6N saline mice. (B) B6J mice treated with poly(I:C) have many significant increases in transcript abundance for innate immune components compared with B6J saline mice. (C) Heatmap showing transcript abundance normalized to saline control for each substrain. Levels for each transcript are shown as log2 fold-change values, normalized to Gusb (n=10/group). Yellow represents high transcript abundance, purple is low transcript abundance. Heirarchical clustering, Welch’s t-test and one-way ANOVA were used to analyze the data (**** P < 0.0001, *** P < 0.0002, ** P < 0.0021, * P < 0.05).