Relationship between Rolandic thalamocortical connectivity and ipsilateral Rolandic spike rate in childhood epilepsy with centrotemporal spikes (CECTS). Among CECTS subjects, there was no relationship found between ipsilateral connectivity index (CI) and each hemisphere’s corresponding spike rate using (A) manual (n = 38 hemispheres, P = .61), (B) Persyst (n = 32 hemispheres, P = .45), and (C) SpikeNet (n = 38 hemispheres, P = .12) techniques. Including only hemispheres with a nonzero spike rate (D-F), a possible relationship was found using SpikeNet (n = 28 hemispheres, P = .05; *statistically significant), but not manual (n = 26 hemispheres, P = .65) or Persyst (n = 30 hemispheres, P = .18) detection. Solid line indicates linear regression model fit; dashed lines indicate 95% confidence intervals