Table 3.

Longitudinal neuropsychological and functional assessments

Assessment*	Annual change (SE) in -SCC group	Annual change (SE) in +SCC group	p-value** (between-group difference in annual change)
MoCA	−0.31 (0.10)	−0.45 (0.09)	0.28
MDRS-2 total score	−0.45 (0.15)	−0.94 (0.14)	0.02
HVLT-R immediate recall	0.10 (0.20)	−0.03 (0.18)	0.62
HLVT-R delayed recall	0.04 (0.13)	0.07 (0.12)	0.87
HVLT-R recognition discrimination	0.06 (0.08)	0.15 (0.08)	0.48
LNS	−0.22 (0.09)	−0.38 (0.08)	0.18
Phonemic verbal fluency (FAS)	−1.01 (0.35)	−1.34 (0.33)	0.48
Animal fluency	−0.77 (0.17)	−0.88 (0.16)	0.65
Trails A (time)	2.04 (0.64)	3.54 (0.61)	0.09
Trails B (time)	6.10 (1.79)	11.31 (1.70)	0.04
SDMT	−1.32 (0.29)	−2.40 (0.27)	0.006
JOLO	−0.26 (0.18)	−0.47 (0.17)	0.41
Clock Drawing	−0.06 (0.05)	−0.01 (0.05)	0.46
BNT	−0.23 (0.08)	−0.18 (0.08)	0.64
ADCS-ADL total	−0.51 (0.33)	−2.16 (0.31)	<0.001
PDAQ KI total	−1.11 (0.32)	−1.50 (0.30)	0.38
PDAQ patient total	−0.62 (0.30)	−0.36 (0.30)	0.54

^*All scores presented are raw scores.

^**Bonferroni corrected significance set at p<0.004 for 14 cognitive tests and at p<.02 for 3 functional measures.

Abbreviations: ADCS-ADL = Alzheimer’s Disease Cooperative Study Activities of Daily Living Inventory; BNT = Boston Naming Test; MDRS-2 = Mattis Dementia Rating Scale-2; MoCA= Montreal Cognitive Assessment; HVLT-R = Hopkins Verbal Learning Test-Revised; SDMT= Symbol Digit Modalities Test; JOLO = Judgment of Line Orientation; LNS = Letter-Number Sequencing; PDAQ-15 = 15-item Penn Parkinson’s Disease Activities Questionnaire.