Table 3:
Full list of results from the ROI-ROI analyses. All analyses controlled for age, sex and motion.
| ROI-ROI connectivity | F | p | |
|---|---|---|---|
| Pre-treatment rsFC: patients (n=61) vs. controls (n=29)* | |||
| 1 | Amygdala-Insula | .145 | .705 |
| 2 | Amygdala-dACC | .446 | .506 |
| 3 | Insula-dACC | .214 | .645 |
| 4 | Amygdala-Hippocampus | .316 | .575 |
| 5 | Insula-Hippocampus | .052 | .820 |
| 6 | dACC-Hippocampus | .626 | .431 |
| 7 | Amygdala-PCC | .557 | .458 |
| 8 | Insula-PCC | 3.043 | .085 |
| 9 | dACC-PCC | .113 | .738 |
| 10 | Hippocampus-PCC | .060 | .808 |
| 11 | Amygdala-vmPFC | 1.257 | .265 |
| 12 | Insula-vmPFC | 1.606 | .209 |
| 13 | dACC-vmPFC | .473 | .493 |
| 14 | Hippocampus-vmPFC | 2.270 | .136 |
| 15 | PCC-vmPFC | .012 | .915 |
| Prediction of treatment outcome based on pre-treatment rsFC (low responders (n=31) vs. high responders (n=24))** | |||
| 1 | Amygdala-Insula | <.001 | .995 |
| 2 | Amygdala-dACC | <.001 | .989 |
| 3 | Insula-dACC | .619 | .435 |
| 4 | Amygdala-Hippocampus | .096 | .758 |
| 5 | Insula-Hippocampus | 1.233 | .273 |
| 6 | dACC-Hippocampus | .697 | .408 |
| 7 | Amygdala-PCC | 7.100 | .011 |
| 8 | Insula-PCC | .075 | .785 |
| 9 | dACC-PCC | .218 | .642 |
| 10 | Hippocampus-PCC | 4.133 | .048 |
| 11 | Amygdala-vmPFC | 1.891 | .176 |
| 12 | Insula-vmPFC | .314 | .578 |
| 13 | dACC-vmPFC | .362 | .550 |
| 14 | Hippocampus-vmPFC | .461 | .500 |
| 15 | PCC-vmPFC | 1.003 | .322 |
| Association between changes in rsFC and treatment outcome (low responders (n=17) vs. high responders (n=22))** | |||
| 1 | Amygdala-Insula | 1.213 | .280 |
| 2 | Amygdala-dACC | .143 | .708 |
| 3 | Insula-dACC | 5.142 | .031 |
| 4 | Amygdala-Hippocampus | .334 | .568 |
| 5 | Insula-Hippocampus | .790 | .381 |
| 6 | dACC-Hippocampus | .641 | .430 |
| 7 | Amygdala-PCC | 1.458 | .237 |
| 8 | Insula-PCC | .056 | .815 |
| 9 | dACC-PCC | .055 | .816 |
| 10 | Hippocampus-PCC | 1.597 | .216 |
| 11 | Amygdala-vmPFC | .057 | .813 |
| 12 | Insula-vmPFC | .227 | .637 |
| 13 | dACC-vmPFC | .374 | .545 |
| 14 | Hippocampus-vmPFC | 1.737 | .197 |
| 15 | PCC-vmPFC | .195 | .662 |
*
IV: group (patients, controls)
**
IVs: group (low responders, high responders), arm (PE+PLB, SERT+EMM, PE+SERT)