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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: FASEB J. 2020 Aug 24;34(10):13900–13917. doi: 10.1096/fj.202001515R

Figure 8: PKI acts as a molecular switch downstream of GPCR-Gαs signaling.

Figure 8:

Simplified model depicting the findings of our study. PKI expression levels can alter the activation state of PKA, leading to the disruption of PKA modulation of cAMP levels and MAPK. In turn, increased levels of cAMP can lead to activation of EPAC and RAP1, which can lead to increase MEK and ERK phosphorylation. Dotted lines indicate indirect regulation of the target.