TABLE 4.
Relation of Insulin Signaling and Related Measures to AD Neuropathology Quartiles
| Odds Ratio (95% CI), p | ||
|---|---|---|
| Predictor | Amyloid Burdena | Tau Tangle Densitya |
| ELISA | ||
| pS307IRS1/total IRS1 | 1.106 (0.817, 1.497), 0.516 | 0.847 (0.626, 1.148), 0.285 |
| pT308AKT1/total AKT1 | 1.350 (1.000, 1.823), 0.050 | 1.373 (1.016, 1.855), 0.039 |
| Immunohistochemistry | ||
| IRS1 cells/mm2 | 1.010 (0.731, 1.386), 0.970 | 1.068 (0.775, 1.472), 0.686 |
| Ex vivo stimulation | ||
| IRS1 recruitment to IRβ | 0.827 (0.543, 1.260), 0.377 | 0.844 (0.555, 1.282), 0.425 |
| pS473AKT1 | 0.709 (0.463, 1.086), 0.114 | 0.923 (0.609, 1.398), 0.705 |
| pT308AKT1 | 0.750 (0.495, 1.135), 0.173 | 0.894 (0.594, 1.345), 0.591 |
| pY1150/1151IRβ | 0.703 (0.456, 1.083), 0.110 | 0.877 (0.577, 1.333), 0.539 |
| pY960IRβ | 0.650 (0.423, 0.999), 0.050 | 0.757 (0.498, 1.152), 0.194 |
Separate ordinal logistic regression models (1 per row) are adjusted for age at death, sex, and education.
a
Quartiles of the outcome.
CI = confidence interval; ELISA = enzyme-linked immunosorbent assay.