TABLE 6.

Relation of Insulin Signaling and Related Measures to Level of Cognitive Function Proximate to Death

Predictor	Estimate (SE) p
	Global Cognition	Cognitive Domains
		Episodic Memory	Working Memory	Semantic Memory	Perceptual Speed	Visuospatial Abilities
ELISA
pS307IRS1/total IRS1	0.086 (0.101) 0.396	0.081 (0.123) 0.511	−0.000 (0.087) 0.999	0.170 (0.116) 0.145	0.188 (0.098) 0.058	0.072 (0.078) 0.362
pT308AKT1/total AKT1	−0.212 (0.097) 0.031a	−0.285 (0.118) 0.017a	−0.234 (0.082) 0.005a	−0.105 (0.113) 0.356	−0.166 (0.096) 0.085	−0.052 (0.076) 0.496
Immunohistochemistry
IRS1 cells/mm2	−0.003 (0.019) 0.875	−0.006 (0.023) 0.790	0.008 (0.017) 0.611	−0.007 (0.022) 0.750	−0.010 (0.019) 0.600	−0.006 (0.015) 0.688
Ex vivo stimulation
IRS1 recruitment to IRβ	0.015 (0.148) 0.922	0.048 (0.174) 0.782	0.007 (0.121) 0.954	0.117 (0.175) 0.506	−0.074 (0.141) 0.600	0.095 (0.112) 0.403
pS473AKT1	0.094 (0.147) 0.525	−0.035 (0.173) 0.839	0.057 (0.121) 0.639	0.226 (0.173) 0.196	0.178 (0.139) 0.205	0.151 (0.111) 0.180
pT308AKT1	0.097 (0.145) 0.507	0.048 (0.170) 0.778	−0.001 (0.119) 0.994	0.265 (0.169) 0.122	0.176 (0.137) 0.212	0.071 (0.111) 0.521
pY1150/1151IRβ	0.156 (0.147) 0.294	0.205 (0.172) 0.239	0.170 (0.120) 0.160	0.294 (0.173) 0.093	0.143 (0.140) 0.311	0.127 (0.112) 0.262
pY960IRβ	0.083 (0.147) 0.575	−0.026 (0.173) 0.883	0.065 (0.120) 0.593	0.124 (0.174) 0.481	0.005 (0.141) 0.974	0.105 (0.112) 0.349

Separate linear regression models were adjusted for age at death, sex, and education.

^aStatistically significant.

ELISA = enzyme-linked immunosorbent assay; SE = standard error.