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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Cell Physiol. 2020 Jun 8;236(1):340–353. doi: 10.1002/jcp.29846

FIGURE 7.

FIGURE 7

Inhibition of extracellular-regulated kinase 1/2 (ERK 1/2) blocks maresin 1 (MaR1)-stimulated increase in [Ca2+]i and high molecular weight glycoprotein secretion. Goblet cells were preincubated with the ERK 1/2 inhibitor UO126 (10−8–10−6 M) for 30 min and stimulated with MaR1 at 10−8 M for [Ca2+]i or 10−9 M for secretion or carbachol (Cch, 10−5 M). Changes in [Ca2+]i over time are shown in (a). Changes in peak [Ca2+]i are shown in (b). Secretion is shown in (c). Data are mean ± SEM of three experiments. *Significance above basal. #Significance from MaR1 or Cch. Arrow indicates addition of MaR1. [Ca2+]i, intracellular Ca2+; SEM, standard error of the mean