FIGURE 9.

Maresin 1 (Mar1) counterregulates histamine-stimulated increase in [Ca²⁺]_i and high molecular weight glycoprotein secretion. Rat conjunctival goblet cells were preincubated with MaR1 at 10⁻⁸ M for [Ca²⁺]_i or 10⁻⁹ M for secretion for 30 min, then stimulated with histamine (10⁻⁵ M). Changes in [Ca²⁺]_i over time are shown in (a) and changes in peak [Ca²⁺]_i are shown in (b). Secretion is shown in (c). Data are mean ± SEM of eight (a and b) and four (c) experiments. *Significance from basal. #Significance between histamine alone. [Ca²⁺]_i, intracellular Ca²⁺; SEM, standard error of the mean