Table 3.
Incidence of osteoarthritis in patients who received ticagrelor versus clopidogrel
| Before PS-matching | After PS-matching | |||
|---|---|---|---|---|
| Treatment | Ticagrelor (n = 7007) |
Clopidogrel (n = 112940) |
Ticagrelor (n = 7007) |
Clopidogrel (n = 14014) |
| Patients diagnosed with OA, n (%) | 534 (7.6) | 17844 (15.8) | 534 (7.6) | 1429 (10.2) |
| Person-years | 8505 | 209396 | 8505 | 16013 |
| IR (95% CI)* | 62.8 (57.7–68.4) | 85.2 (84.0–86.5) | 62.8 (57.7–68.4) | 89.2 (84.7–93.4) |
| HR (95% CI)† | 0.68 (0.63–0.74) | 1.0 | 0.71 (0.64–0.79) | 1.0 |
PS = propensity score; OA = osteoarthritis;
*
IR = incidence rate per 1,000 person-years;
†
HR = adjusted hazard ratio; 95% CI = 95% confidence interval. Incidence rate was estimated with Poisson regression of log link.