Representative 3D μCT imaging to assess peri-implant bone formation in cases treated with (A) L-PBS or (B) L-WNT3A. Sirius red staining observed with polarized light of representative sections from (C) L-PBS and (D) L-WNT3A. (E) Quantification of Bone Volume over Total Volume in the gap region. (F) Lateral stability testing of implants treated with L-PBS or L-WNT3A on PID7 (N=8, p=0.34). Collagen Type I expression observed in representative sections from (G) L-PBS and (H) L-WNT3A. Vimentin expression in representative sections from (I) L-PBS and (J) L-WNT3A. On PID7, Pentachrome staining of representative sagittal sections of (K) L-PBS and (L) L-WNT3A treated sites. Scale bars = 200μm (A, B), 50μm (G-L). Abbreviations: b, bone; IM, implant. Asterisk indicates p<.05.