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. 2020 Dec 7;8:219. doi: 10.1186/s40478-020-01092-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — H3.3G34V Co-enriches With Wild-type H3.3. a Relative proportion of H3.3WT enrichment across gene elements with H3.3G34V expression or knock-down. b H3.3 enrichment at SOX2 was greatest KNS42 cell s expressing H3.3G34V, compared to NHAs lacking H3.3G34V expression (red highlight) or after H3.3G34V transduction. c, d Co-enrichment of H3.3G34V and H3.3WT was observed across experimental conditions at the top 10,000 loci most-enriched for C) H3.3G34V, and D) H3.3WT in transduced KNS42 cells without DOX induction. e When the top 10,000 loci most enriched for H3.3G34V, H3.3 wild-type, H3K36me3 and H3K27me3 in transduced KNS42 cells without DOX induction are compared, greatest overlap is observed between H3.3G34V and wild-type H3.3 enrichments patterns, with 3041 common loci between these two groups