Fig. 1.

Mouse model of HSV-2 latent infection in the SC. a Anatomical scheme explaining HSV-2 access into the SC through a genital infection and simplified scheme of the SC: WM (white matter), GM (gray matter), DH (dorsal horn), IG (intermediate gray), VH (ventral horn), L I (lamina I), L II (lamina II), L IX (lamina IX) b Scheme of the HSV-2 latently infected SC mouse model. c Disease score of Mock and HSV-2 infected mice; measurements were performed every 2 days (n = 15). d Gain weight of Mock and HSV-2 infected mice; measurements were performed every 2 days (n = 15). e q-PCR analysis of LAT expression in the SC of Mock (n = 7) and HSV-2 (n = 10) from two independent experiments. An arbitrary cut-off value 3 (dotted-line) was established to consider a SC positive for LAT expression. Disease score values and LAT expression defined the HSV-2^esi category used in this manuscript