Fig. 8.

Cerulenin blocks LPS-induced loss of spatial and short-term memory. a Experimental scheme. Cerulenin (6 nmol per animal) or vehicle (water) was injected into the left ventricle. One hour later, LPS (3 μg per animal) or vehicle (CTL:1x PBS) was injected again. One week later, Y-maze test was performed to assess spatial memory. Two weeks later, passive avoidance test was performed followed by perfusion fixation of the brains. b Percent alternations in Y-maze test. c Latency in seconds in passive avoidance test. d NeuN immunostaining in CA3 region of hippocampus. Florescence intensity of the immunostaining was shown on the right. Bar = 50 μm. Mean + SE, n = 3–8. #P < 0.05, compared to CTL. *P < 0.05 compared to vehicle