Table 2.
Correlation between the expression of ITG genes and OS in GC patients at different clinical stages.
| ITGs (RNA-seq) | Differentiation: I (n = 12); II (n = 134); III (n = 218); | HR (95% CI) | P-value |
|---|---|---|---|
| ITGA1 (none) | Grade I | — | — |
| Grade II | 1.11 (0.63–1.94) | 0.73 | |
| Grade III | 1.34 (0.89–2.03) | 0.16 | |
| ITGA2 | Grade I | — | — |
| Grade II | 0.53 (0.3–0.94) | 0.03 | |
| Grade III | 1.26 (0.83–1.89) | 0.28 | |
| ITGA3 | Grade I | — | — |
| Grade II | 0.69 (0.39–1.21) | 0.19 | |
| Grade III | 1.16 (0.77–1.75) | 0.48 | |
| ITGA4 | Grade I | — | — |
| Grade II | 1.1 (0.63–1.94) | 0.73 | |
| Grade III | 1 (0.66–1.5) | 0.99 | |
| ITGA5 | Grade I | — | — |
| Grade II | 0.97 (0.55–1.69) | 0.9 | |
| Grade III | 1.43 (0.95–2.16) | 0.09 | |
| ITGA6 | Grade I | — | — |
| Grade II | 0.52 (0.29–0.93) | 0.02 | |
| Grade III | 0.8 (0.53–1.21) | 0.3 | |
| ITGA7 | Grade I | — | — |
| Grade II | 0.93 (0.93–1.63) | 0.8 | |
| Grade III | 1.08 (0.72–1.63) | 0.7 | |
| ITGA8 | Grade I | — | — |
| Grade II | 1.13 (0.64–1.98) | 0.67 | |
| Grade III | 1.07 (0.71–1.61) | 0.76 | |
| ITGA9 | Grade I | — | — |
| Grade II | 1.1 (0.63–1.93) | 0.74 | |
| Grade III | 1.19 (079–1.79) | 0.4 | |
| ITGA10 | Grade I | — | — |
| Grade II | 0.78 (0.44–1.38) | 0.39 | |
| Grade III | 1.38 (0.91–2.09) | 0.13 | |
| ITGA11 | Grade I | — | — |
| Grade II | 1.72 (0.96–3.1) | 0.07 | |
| Grade III | 1.34 (0.88–2.03) | 0.17 | |
| ITGAD | Grade I | — | — |
| Grade II | 0.87 (0.49–1.54) | 0.63 | |
| Grade III | 0.7 (046–1.07) | 0.096 | |
| ITGAE | Grade I | — | — |
| Grade II | 2.2 (1.23–3.93) | 0.03 | |
| Grade III | 0.45 (0.28–0.72) | 0.02 | |
| ITGAL | Grade I | — | — |
| Grade II | 1.79 (0.93–3.44) | 0.07 | |
| Grade III | 0.66 (0.44–1) | 0.05 | |
| ITGAM | Grade I | — | — |
| Grade II | 1.54 (0.88–2.7) | 0.13 | |
| Grade III | 1.39 (0.92–2.12) | 0.12 | |
| ITGAV | Grade I | — | — |
| Grade II | 0.51 (0.29–0.92) | 0.02 | |
| Grade III | 2.34 (1.55–3.54) | <0.01 | |
| ITGAX | Grade I | — | — |
| Grade II | 1.7 (0.97–3.01) | 0.06 | |
| Grade III | 0.99 (0.65–1.49) | 0.95 | |
| ITGB1 | Grade I | — | — |
| Grade II | 0.65 (0.37–1.15) | 0.13 | |
| Grade III | 1.59 (1.05–2.42) | 0.02 | |
| ITGB2 | Grade I | — | — |
| Grade II | 1.2 (0.68–2.1) | 0.53 | |
| Grade III | 0.85 (0.56–1.28) | 0.43 | |
| ITGB3 | Grade I | — | — |
| Grade II | 1.01 (0.58–1.77) | 0.97 | |
| Grade III | 1.49 (0.98–2.26) | 0.06 | |
| ITGB4 | Grade I | — | — |
| Grade II | 0.83 (0.47–1.46) | 0.5 | |
| Grade III | 1.09 (0.72–1.64) | 0.7 | |
| ITGB5 | Grade I | — | — |
| Grade II | 1.12 (0.64–1.97) | 0.69 | |
| Grade III | 1.54 (1.01–2.35) | 0.05 | |
| ITGB6 | Grade I | — | — |
| Grade II | 0.9 (0.51–1.6) | 0.73 | |
| Grade III | 1.22 (0.81–1.83) | 0.35 | |
| ITGB7 | Grade I | — | — |
| Grade II | 1.28 (0.73–2.26) | 0.39 | |
| Grade III | 0.94 (0.64–1.45) | 0.85 | |
| ITGB8 | Grade I | — | — |
| Grade II | 0.92 (0.52–1.62) | 0.77 | |
| Grade III | 1.01 (0.67–1.53) | 0.95 |